期刊
NATURE IMMUNOLOGY
卷 13, 期 9, 页码 857-863出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2372
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- National Health and Medical Research Council of Australia
- Australian Research Council
- Cancer Council of Victoria
- US National Institutes of Health [AI090450, AI092108]
- Swedish Research Council
- Swedish Cancer Society
- Monash University
Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A' pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F' pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCR alpha and TCR beta chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.
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