期刊
NATURE IMMUNOLOGY
卷 13, 期 4, 页码 352-357出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2228
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资金
- US National Institutes of Health [R37-AI029564-17, CA-156330-01]
- Cancer Research Institute
- Science Foundation Ireland
The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1 beta (IL-1 beta) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.
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