期刊
NATURE IMMUNOLOGY
卷 13, 期 8, 页码 753-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2360
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资金
- National Heart, Lung and Blood Institute [2T32HL007317-31]
- Fondazione Beretta
- Programma di Ricerca di interesse Nazionale of the Ministero dell'Istruzione dell'Universite della Ricerca
- European Commission
- US National Institutes of Health [GM77279, HL097805]
The differentiation of bone marrow-derived progenitor cells into monocytes, tissue macrophages and some dendritic cell (DC) subtypes requires the growth factor CSF1 and its receptor, CSF1R. Langerhans cells (LCs) and microglia develop from embryonic myeloid precursor cells that populate the epidermis and central nervous system (CNS) before birth. Notably, LCs and microglia are present in CSF1-deficient mice but absent from CSF1R-deficient mice. Here we investigated whether an alternative CSF1R ligand, interleukin 34 (IL-34), is responsible for this discrepancy. Through the use of IL-34-deficient (Il34(LacZ/LacZ)) reporter mice, we found that keratinocytes and neurons were the main sources of IL-34. Il34(LacZ/LacZ) mice selectively lacked LCs and microglia and responded poorly to skin antigens and viral infection of the CNS. Thus, IL-34 specifically directs the differentiation of myeloid cells in the skin epidermis and CNS.
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