期刊
NATURE IMMUNOLOGY
卷 13, 期 9, 页码 808-810出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2396
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- NCI NIH HHS [R01 CA160417] Funding Source: Medline
The characteristics of the tumor microenvironment vary widely. New work shows that after tumor-associated expression of the receptor TIM-3 by dendritic cells, TIM-3 inhibits the antitumor efficacy of DNA vaccines and chemotherapy by binding to the damage-associated molecular pattern molecule, HMGB1.
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