期刊
NATURE IMMUNOLOGY
卷 12, 期 8, 页码 715-723出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2060
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资金
- Israel Science Foundation
- Crohn's & Colitis Foundation of America
- German-Israeli Foundation
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- US National Institutes of Health
- American Cancer Society
- Israel Cancer Research Fund
Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-kappa B in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-kappa B has a confounding role in certain tumors. Understanding the activity and function of NF-kappa B in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.
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