期刊
NATURE IMMUNOLOGY
卷 12, 期 6, 页码 527-U243出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2036
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资金
- US National Institutes of Health [AI026918, AI077439]
- Howard Hughes Medical Institute
- Sandler Asthma Basic Research Center at the University of California San Francisco, San Francisco
Contributions by basophils to allergic and helminth immunity remain incompletely defined. Using sensitive interleukin 4 (Il4) reporter alleles, we demonstrate here that basophil IL-4 production occurs by a CD4(+) T cell-dependent process restricted to the peripheral tissues affected. We genetically marked and achieved specific deletion of basophils and found that basophils did not mediate T helper type 2 (T(H)2) priming in vivo. Two-photon imaging confirmed that basophils did not interact with antigen-specific T cells in lymph nodes but engaged in prolonged serial interactions with T cells in lung tissues. Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity.
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