期刊
NATURE IMMUNOLOGY
卷 12, 期 10, 页码 949-U54出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2105
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资金
- Ministere de la Recherche
- Association pour la Recherche sur le Cancer
- Swiss National Science Foundation
- Fondation Sante
- Institut Pasteur
- Universite Paris Diderot
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale de Recherches
The transcription factor ROR gamma t is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of ROR gamma t(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin alpha(4)beta(7) and CXCR6. Whereas fetal ROR gamma t(+) cells matured in the fetal liver environment, adult bone marrow-derived ROR gamma t(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of ROR gamma t(+) cells differently.
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