期刊
NATURE IMMUNOLOGY
卷 12, 期 11, 页码 1045-U47出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2131
关键词
-
类别
资金
- US National Institutes of Health [U19AI083022, AI071309, HHSN266200500030C, HL098957, AI061570, AI074878, AI087990, AI095608, AI091759, AI095466, U01AI095608, T32AI007532, T32AI05528]
- Burroughs Wellcome Fund
- National Institute of Diabetes and Digestive and Kidney Diseases Center for the Molecular Studies in Digestive and Liver Diseases Molecular Pathology and Imaging Core [DK50306]
- University of Pennsylvania
Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue homeostasis at other mucosal sites remains poorly characterized. Here we identify a population of lung-resident ILCs in mice and humans that expressed the alloantigen Thy-1 (CD90), interleukin 2 (IL-2) receptor alpha-chain (CD25), IL-7 receptor alpha-chain (CD127) and the IL-33 receptor subunit T1-ST2. Notably, mouse ILCs accumulated in the lung after infection with influenza virus, and depletion of ILCs resulted in loss of airway epithelial integrity, diminished lung function and impaired airway remodeling. These defects were restored by administration of the lung ILC product amphiregulin. Collectively, our results demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after infection with influenza virus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据