期刊
NATURE IMMUNOLOGY
卷 12, 期 7, 页码 616-U168出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2051
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- Cancer Council of Victoria
- National Health and Medical Research Council of Australia
- Australian Research Council
- Cancer Research Institute
- US National Institutes of Health [AI45889]
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(alpha)14-J(alpha)18) T cell antigen receptor (TCR) alpha-chain and recognition of the glycolipid alpha-galactosylceramide (alpha-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of alpha-GalCer-reactive NKT cells that expressed a canonical V(alpha)10-J(alpha)50 TCR alpha-chain, which showed a preference for alpha-glucosylceramide (alpha-GlcCer) and bacterial a-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCR alpha sequence identity, the V(alpha)10 TCR-CD1d-alpha-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-alpha-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
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