期刊
NATURE IMMUNOLOGY
卷 13, 期 1, 页码 58-U83出版社
NATURE PORTFOLIO
DOI: 10.1038/ni.2182
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资金
- National Institutes of Allergy and Infectious Diseases [AI026918, AI030663, AI077439]
- Howard Hughes Medical Institute
- Sandler Asthma Basic Research Center at the University of California San Francisco
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI077439, R01AI030663, R01AI026918, R37AI026918] Funding Source: NIH RePORTER
Interleukin 4 (IL-4) and IL-13 are critical for responses to parasitic helminthes. We used genetically engineered reporter mice to assess the temporal and spatial production of these cytokines in vivo. In lymph nodes, IL-4, but not IL-13, was made by follicular helper T cells (T-FH cells). In contrast, tissue type 2 helper T cells (T(H)2 cells) produced both cytokines. There was also divergent production of IL-4 and IL-13 among cells of the innate immune system, whereby basophils produced IL-4, whereas innate helper type 2 cells (Ih2 cells) produced IL-13. IL-13 production by T(H)2 and Ih2 cells was dependent on the transcription factor GATA-3, which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in T-FH cells and basophils. The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity.
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