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Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment
Kiran Nistala et al.
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Preferential Recruitment of Interferon-γ-Expressing TH17 Cells in Multiple Sclerosis
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T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation
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Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
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Ectopic T-bet Expression Licenses Dendritic Cells for IL-12-Independent Priming of Type 1 T Cells In Vitro
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T-bet Inhibits the In Vivo Differentiation of Parasite-Specific CD4+ Th17 Cells in a T Cell-Intrinsic Manner
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Development of Allergen-Induced Airway Inflammation in the Absence of T-bet Regulation Is Dependent on IL-17
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Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles
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Expression of TH1 and TH17 cytokines and transcription factors in multiple sclerosis patients: Does baseline T-Bet mRNA predict the response to interferon-beta treatment?
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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
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Bcl6 Mediates the Development of T Follicular Helper Cells
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T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children
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CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice
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Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
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IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells
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Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
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The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction
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Transcription factors T-bet and Runx3 cooperate to activate lfng and silence ll4 in T helper type 1 cells
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pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity
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The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
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Transforming growth factor-β induces development of the TH17 lineage
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Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
JS Wang et al.
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TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
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T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
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T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
GM Lord et al.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
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Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection
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The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells
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CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
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T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
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T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
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The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
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T-bet regulates IgG class switching and pathogenic autoantibody production
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Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
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T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
AA Lighvani et al.
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Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion
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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
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A novel transcription factor, T-bet, directs Th1 lineage commitment
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