期刊
NATURE IMMUNOLOGY
卷 11, 期 10, 页码 889-896出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1937
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资金
- Biomedical Research Council, Agency for Science, Technology Research
- European Commission
- Italian Association for Cancer Research
Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
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