期刊
NATURE IMMUNOLOGY
卷 11, 期 8, 页码 701-U66出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1890
关键词
-
类别
资金
- Institut National de la Sante et de la Recherche Medicale
- Centre d'Investigation Clinique en Biotherapie 507 Institut National de la Sante et de la Recherche Medicale
- Agence National de Recherches
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR)alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1. Here we show that MAIT cells were activated by cells infected with various strains of bacteria and yeast, but not cells infected with virus, in both humans and mice. This activation required cognate interaction between the invariant TCR and MR1, which can present a bacteria-derived ligand. In humans, we observed considerably fewer MAIT cells in blood from patients with bacterial infections such as tuberculosis. In the mouse, MAIT cells protected against infection by Mycobacterium abscessus or Escherichia coli. Thus, MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据