期刊
NATURE IMMUNOLOGY
卷 11, 期 7, 页码 594-U60出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1885
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资金
- Japan Society for the Promotion of Science
- US National Institutes of Health [R01NS065048]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labour and Welfare
- National Institute of Biomedical Innovation
- Japan Science and Technology Agency
- Uehara Memorial Foundation
- Takeda Scientific Foundation
- Grants-in-Aid for Scientific Research [21590196] Funding Source: KAKEN
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
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