期刊
NATURE IMMUNOLOGY
卷 10, 期 3, 页码 297-305出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1693
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资金
- Canadian Institutes of Health Research
- Canadian Cancer Society
- Howard Hughes Medical Institute
- Cancer Research Society
- Canada Research Chair Program
- Clinical Research Institute of Montreal
- Terry Fox Foundation
CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
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