期刊
NATURE IMMUNOLOGY
卷 10, 期 12, 页码 1267-U6出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1816
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资金
- US National Institutes of Health [R01 DK61707, T32-HL007517]
- Swiss National Science Foundation
- University of Michigan Comprehensive Cancer Center
- Spanish Ministerio de Cienciae Innovacion [SAF2007-61716]
- European Union
- Comunidad de Madrid [S-SAL-0159/2006]
- La Red Tematica de Investigacion Cooperativa en Enfermedades Cardiovasculares [RD06/0014/1013]
Nod2 belongs to the nucleotide-binding oligomerization domain receptor (NLR) family of proteins, which function as intracellular pathogen sensors in innate immune cells. Nod2 deficiency results in an impaired immune response to bacterial pathogens. However, how this protein promotes host defense against intracellular parasites is unknown. Here we found that Nod2(-/-) mice had less clearance of Toxoplasma gondii and lower interferon-gamma(IFN-gamma) production. Reconstitution of T cell-deficient mice with Nod2(-/-) T cells followed by T. gondii infection demonstrated a T cell-intrinsic defect. Nod2(-/-) CD4(+) T cells had poor helper T cell differentiation, which was associated with impaired production of interleukin 2 (IL-2) and nuclear accumulation of the transcription factor subunit c-Rel. Our data demonstrate a T cell-intrinsic role for Nod2 signaling that is critical for host defense against T. gondii.
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