期刊
NATURE IMMUNOLOGY
卷 10, 期 7, 页码 706-U54出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1737
关键词
-
类别
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology [18073016]
- Japan Society for the Promotion of Science [20390145, 19390121]
- Japanese Ministry of Health, Labor and Welfare
- Grants-in-Aid for Scientific Research [19390121, 20390145, 18073016] Funding Source: KAKEN
Basophils express major histocompatibility complex class II, CD80 and CD86 and produce interleukin 4 (IL-4) in various conditions. Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4. Intravenous administration of ovalbumin-pulsed basophils into naive mice 'preferentially' induced the development of naive ovalbumin-specific CD4(+) T cells into T helper type 2 (T(H)2) cells. Mice immunized in this way, when challenged by intravenous administration of ovalbumin, promptly produced ovalbumin-specific IgG1 and IgE. Finally, intravenous administration of IgE complexes rapidly induced T(H)2 cells only in the presence of endogenous basophils, which suggests that basophils are potent antigen-presenting cells that 'preferentially' augment T(H)2-IgE responses by capturing IgE complex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据