期刊
NATURE IMMUNOLOGY
卷 10, 期 9, 页码 934-936出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0909-934
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- NEI NIH HHS [R01 EY016408-05, R01 EY016408] Funding Source: Medline
- NIAID NIH HHS [P01 AI035297-180009, P01 AI035297] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007618] Funding Source: Medline
While promiscuous expression of tissue-specific antigens (TSAs) in the thymus is essential for self-tolerance, immunologically relevant TSA expression may also occur in the secondary lymphoid organs. A new study links the transcriptional regulator Deaf1 with altered TSA expression in the secondary lymphoid organs and autoimmune diabetes.
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