期刊
NATURE IMMUNOLOGY
卷 10, 期 5, 页码 455-457出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0509-455
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The 3020insC mutation in Nod2 is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine.
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