期刊
NATURE IMMUNOLOGY
卷 10, 期 8, 页码 817-821出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1776
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资金
- US National Institutes of Health
- Damon Runyon Cancer Research Foundation [DRG-1981-08]
During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D) J) recombination. In the past 20 years, a great deal has been learned about the enzymatic activities of the RAG-1-RAG-2 complex. Recent studies have identified several new and exciting regulatory functions of the RAG-1-RAG-2 complex. Here we discuss some of these functions and suggest that the RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D) J recombination factory'.
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