期刊
NATURE IMMUNOLOGY
卷 9, 期 11, 页码 1215-1223出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.f.216
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- NCI NIH HHS [R01 CA072074-15, R01 CA072074] Funding Source: Medline
- NIAID NIH HHS [R01 AI023990, R01 AI070813-01, R01 AI023990-20, R01 AI070813] Funding Source: Medline
Mast cells can function as effector and immunoregulatory cells in immunoglobulin E-associated allergic disorders, as well as in certain innate and adaptive immune responses. This review focuses on exciting new developments in the field of mast cell biology published in the past year. We highlight advances in the understanding of Fc epsilon RI-mediated signaling and mast cell-activation events, as well as in the use of genetic models to study mast cell function in vivo. Finally, we discuss newly identified functions for mast cells or individual mast cell products, such as proteases and interleukin 10, in host defense, cardiovascular disease and tumor biology and in settings in which mast cells have anti-inflammatory or immunosuppressive functions.
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