期刊
NATURE IMMUNOLOGY
卷 9, 期 12, 页码 1425-1432出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1664
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资金
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Louis Pasteur University
- Alsace Region
- US National Institutes of Health [PO1 AI070167]
- Agence Nationale de Recherche Microbiologie-Maladie Emergentes
Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.
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