期刊
NATURE IMMUNOLOGY
卷 10, 期 1, 页码 101-108出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1675
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资金
- European Union Sixth Framework Programme [LSHB-CT-2005-518167]
- Deutsche Forschungsgemeinschaft [SE 888/4-1]
- Else-Kroner Fresenius Stiftung
- MRC [G0401634] Funding Source: UKRI
- Medical Research Council [G0401634] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [P30CA068485, R01CA034590] Funding Source: NIH RePORTER
The Duffy antigen receptor for chemokines (DARC) belongs to a family of 'silent' heptahelical chemokine receptors that do not couple to G proteins and fail to transmit measurable intracellular signals. DARC binds most inflammatory chemokines and is prominently expressed on venular endothelial cells, where its function has remained contentious. Here we show that DARC, like other silent receptors, internalized chemokines but did not effectively scavenge them. Instead, DARC mediated chemokine transcytosis, which led to apical retention of intact chemokines and more leukocyte migration across monolayers expressing DARC. Mice overexpressing DARC on blood vessel endothelium had enhanced chemokine-induced leukocyte extravasation and contact-hypersensitivity reactions. Thus, interactions of chemokines with DARC support their activity on apposing leukocytes in vitro and in vivo.
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