期刊
SLEEP
卷 38, 期 7, 页码 1085-U103出版社
OXFORD UNIV PRESS INC
DOI: 10.5665/sleep.4818
关键词
cross-frequency coupling; Hilbert-Huang transform; hippocampus; monkey; REM sleep
资金
- Japan Society for the Promotion of Science [23500471, 24300192]
- Grants-in-Aid for Scientific Research [15H05880, 23500471, 15H05871, 26112005] Funding Source: KAKEN
Study Objectives: The mechanism by which sleep consolidates memory is unclear. Based on the two-stage model of memory consolidation, different functions for slow wave sleep (SWS) and rapid eye movement (REM) sleep have been proposed; thus, state-dependent changes of neural oscillations in the hippocampus might clarify this fundamental question. Methods: We recorded hippocampal local field potentials from freely behaving monkeys via telemetry and analyzed their nonstationary oscillations using Hilbert-Huang transform. Results: By applying a recently developed empirical mode decomposition analysis, we found strong cross-frequency coupling between high-frequency and slow wave oscillations during SWS and a prominent increase of gamma band activity in short bursts during REM sleep in unanesthetized primates' hippocampus. Conclusion: Spatiotemporal integration through coupled oscillations during slow wave sleep might be a physiological basis of system consolidation, whereas gamma bursts during rapid eye movement sleep might be related to synaptic consolidation in the local hippocampal neural circuit.
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