期刊
NATURE IMMUNOLOGY
卷 9, 期 5, 页码 551-557出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1602
关键词
-
类别
资金
- NCI NIH HHS [R01 CA078846, R01 CA078846-08] Funding Source: Medline
- NIAID NIH HHS [R01 AI068842, U19 AI057234-01, U19 AI057234, R37 AI034098, R01 AI068842-01, R37 AI034098-07, R01 R37AI34098] Funding Source: Medline
Although plasmacytoid dendritic cells (pDCs) respond to virus replication in a nonspecific way by producing large amounts of type I interferon, a rapid, direct function for pDCs in activating antiviral lymphocytes is less apparent. Here we show that pDCs were able to rapidly initiate antigen-specific antiviral CD8(+) T cell responses. After being exposed to virus, pDCs efficiently and rapidly internalized exogenous viral antigens and then presented those antigens on major histocompatibility complex (MHC) class I to CD8(+) T cells. Processing of exogenous antigen occurred in endocytic organelles and did not require transit of antigen to the cytosol. Intracellular stores of MHC class I partially localized together with the transferrin receptor and internalized transferrin in endosomes, which suggested that such recycling endosomes are sites for loading peptide onto MHC class I or for peptide transit. Our data demonstrate that pDCs use `ready-made' stores of MHC class I to rapidly present exogenous antigen to CD8(+) T cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据