期刊
NATURE IMMUNOLOGY
卷 9, 期 3, 页码 239-244出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1572
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- NIAID NIH HHS [R37 AI046643, R37 AI046643-11] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI046643] Funding Source: NIH RePORTER
The function of regulatory T cells (T-reg cells) has been attributed to a growing number of diverse pathways, molecules and processes. Seemingly contradictory conclusions regarding the mechanisms underlying T-reg cell suppressive activity have revitalized skeptics in the field who challenge the core validity of the idea of T-reg cells as central immune regulators. However, we note that a consensus may be emerging from the data: that multiple T-reg cell functions act either directly or indirectly at the site of antigen presentation to create a regulatory milieu that promotes bystander suppression and infectious tolerance. Thus, the versatility and adaptability of the Foxp3(+) T-reg cells may in fact be the best argument that these cells are 'multitalented masters of immune regulation'.
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