期刊
NATURE IMMUNOLOGY
卷 9, 期 2, 页码 113-115出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0208-113
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Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth muscle and on bone marrow-derived inflammatory cells. K. Frank Austen describes the work culminating in the identification, biosynthesis and functional characterization of these moieties.
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