期刊
NATURE GENETICS
卷 50, 期 10, 页码 1412-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-018-0205-x
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资金
- National Institute for Health Research (NIHR)
- Medical Research Council [MR/L01632X.1, MR/L01632X/1, MR/L016311/1]
- MRC eMedLab Medical Bioinformatics Career Development Fellowship [MR/L016311/1]
- NIHR Imperial College Health Care NHS Trust
- Imperial College London Biomedical Research Centre
- Canadian Institutes of Health Research
- Universite Laval (Quebec City, Canada)
- Canada Research Chair in Genetic and Molecular Epidemiology
- CISCO Professorship in Integrated Health Biosystems
- EU PhenoMeNal project (Horizon 2020) [654241]
- NIH-NIDDK [U01DK102163]
- European Research Council (ERC)
- EU Joint Programme Neurodegenerative Disease Research (JPND)
- Agence Nationale de la Recherche (ANR)
- core MRC grant
- NIH [R01-DK062370, CRR00070 CR00.01, R01DK110113, U01HG007417, R01DK101855, R01DK107786]
- Tripartite Immunometabolism Consortium (TrIC)
- Novo Nordisk Foundation [NNF15CC0018486]
- Marie Sklodowska-Curie GF grant [661395]
- ICIN-NHI
- MRC AimHy [MR/M016560/1]
- Data Tecnica International
- National Institute on Aging, NIH
- Italian Ministry of Health [RF2010, RC2008]
- Royal Netherlands Academy of Science Professor Award [PAH/6635]
- Singapore Ministry of Health's National Medical Research Council under its Singapore Translational Research Investigator (STaR) Award [NMRC/STaR/0028/2017]
- National Institutes for Health Research (NIHR)
- NIHR Biomedical Research Centre, Oxford
- China Scholarship Council [2011632047]
- Medical Research Council UK [G1000143, MC_UU_12015/1, MC_PC_13048, MC_U106179471]
- Cancer Research UK [C864/A14136]
- EU FP6 programme [LSHM_CT_2006_037197]
- Swiss National Foundation SPUM project [FN 33CM30-124087]
- Geneva University
- Fondation pour Recherches Medicales, Geneve
- Li Ka Shing Foundation
- WT-SSI/John Fell funds
- Widenlife
- Dutch Science Organization (ZonMW-VENI Grant) [916.14.023]
- National Institute for Health Research ( NIHR) BioResource Clinical Research Facility
- Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
- Wellcome Trust core award [090532/Z/09/Z]
- BHF Centre of Research Excellence [RE/13/1/30181]
- European Union Seventh Framework Programme FP7/2007-2013 [HEALTH-F2-2013-601456]
- Wellcome Trust Institutional strategic support fund
- Forschungs-und Forder-Stiftung INOVA, Liechtenstein
- British Heart Foundation [PG/17/35/33001, RG/13/13/30194, SP/13/2/30111]
- NIHR Senior Investigator Award
- Biomedical Research Centre Award
- Marie Sklodowska-Curie GF [661395]
- Wellcome Trust [WT098051]
- Vanderbilt Molecular and Genetic Epidemiology of Cancer (MAGEC) training program [T32CA160056]
- VA grant [1I01CX000982, I01BX003360]
- NHLBI, NIH [R21HL121429]
- VA Boston Healthcare, Section of Cardiology
- Department of Medicine, Brigham
- Women's Hospital, Harvard Medical School
- UK Medical Research Council [MR/L003120/1]
- UK National Institute for Health Research Cambridge Biomedical Research Centre
- NIHR Biomedical Research Centre at Imperial College Healthcare NHS Trust and Imperial College London
- NIHR Health Protection Research Unit in Health Impact of Environmental Hazards [HPRU-2012-10141]
- Medical Research Council (MRC)
- Public Health England (PHE) Centre for Environment and Health [(MR/L01341X/]
- MRC
- Alzheimer's Society
- Alzheimer's Research UK
- Medical Research Council
- MRC eMedLab award
- NIHR Biomedical Research Centre at Barts
- Marie Curie Actions (MSCA) [661395] Funding Source: Marie Curie Actions (MSCA)
- BBSRC [BB/F019394/1] Funding Source: UKRI
- ESRC [ES/S008349/1] Funding Source: UKRI
- MRC [MC_UU_00007/10, MR/N01104X/2, MC_PC_U127561128, MR/N015746/1, UKDRI-5001, MR/N01104X/1, MR/M004422/1, MR/L01341X/1, MR/L01632X/1, MC_UU_12015/1, MR/R023484/1, MR/S003746/1, MR/N003284/1, MR/K007017/1, G0601966, MR/L003120/1, G1001799] Funding Source: UKRI
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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