期刊
NATURE GENETICS
卷 46, 期 5, 页码 427-429出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2928
关键词
-
资金
- Marsha Rivkin Center for Ovarian Cancer Research
- Anne Rita Monahan Foundation
- Ovarian Cancer Alliance of Arizona
- Small Cell Ovarian Cancer Foundation
- Terry Fox Research Initiative New Frontiers Program in Cancer
- Canadian Institutes of Health Research
Small cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is an extremely rare, aggressive cancer affecting children and young women. We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors. These data implicate SMARCA4 in SCCOHT oncogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据