期刊
NATURE GENETICS
卷 45, 期 6, 页码 580-585出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2653
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资金
- CCR NIH HHS [HHSN261200800001C] Funding Source: Medline
- Intramural NIH HHS [Z99 HG999999] Funding Source: Medline
- NCI NIH HHS [HHSN261200800001E] Funding Source: Medline
- NHLBI NIH HHS [HHSN268201000029C] Funding Source: Medline
- NIDA NIH HHS [R01 DA033684, R01 DA006227-17, R01 DA006227] Funding Source: Medline
- NIMH NIH HHS [R01 MH101819, R01 MH090948, R01 MH090941, R01 MH090951, R01 MH090937, R01 MH090936] Funding Source: Medline
- Wellcome Trust [090532] Funding Source: Medline
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
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