期刊
NATURE GENETICS
卷 45, 期 2, 页码 131-132出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2522
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资金
- Carlos Slim Health Institute in Mexico
- Specialized Program of Research Excellence (SPORE) grant in Soft Tissue Sarcoma [P50 CA140146]
- MSKCC [P01CA47179]
- American Cancer Society AstraZeneca
- Kristen Ann Carr Foundation
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
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