期刊
NATURE GENETICS
卷 45, 期 4, 页码 385-391出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2560
关键词
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资金
- Cancer Research UK [11174, 10588, 11022, 13065, 10118, 14136, 10124] Funding Source: Medline
- Intramural NIH HHS [Z99 CA999999, ZIA CP010195-06] Funding Source: Medline
- Medical Research Council [G0401527, G1000143, G0900871] Funding Source: Medline
- NCATS NIH HHS [TL1 TR000132] Funding Source: Medline
- NCI NIH HHS [R01 CA092579, P30 CA042014, R01 CA092447, P30 CA076292] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007814] Funding Source: Medline
- Prostate Cancer UK [G2011/36] Funding Source: Medline
- Cancer Research UK [13065, 10118, 16561, 14136, 16565, 10588, 11174, 11022, 15007] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Medical Research Council [G0900871, G0401527, G1000143] Funding Source: researchfish
- National Breast Cancer Foundation [IF-12-06] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10242] Funding Source: researchfish
- Prostate Cancer UK [G2011/36] Funding Source: researchfish
- MRC [G0900871] Funding Source: UKRI
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom II lumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genomewide significance (P < 5 x 10(-8)). More than 70 prostate cancer susceptibility loci, explaining similar to 30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
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