期刊
NATURE GENETICS
卷 45, 期 12, 页码 1428-U171出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2800
关键词
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资金
- US National Institutes of Health [R01CA169345, R01CA159467, R21CA143282]
- MD Anderson Cancer Center Bladder Cancer SPORE grant [P50CA091846]
- National Human Genome Research Institute, US National Institutes of Health
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
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