期刊
NATURE GENETICS
卷 45, 期 7, 页码 767-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2644
关键词
-
资金
- European Union [HEALTH-F4-2010-241504]
- Wellcome Trust [090532/Z/09/Z, 083573/Z/07/Z, 089269/Z/09/Z]
- Swedish Research Council [K2008-66X-20776-01-4]
- Harald and Greta Jeanssons Foundation
- Swedish Association for Persons with Neurological Disabilities
- Ake Wibergs Foundation
- Ake Lownertz Foundation
- Karolinska Institutet funds
- European Union's Sixth Framework Programme EURATools [LSHG-CT-2005-019015]
- Bibbi and Nils Jensens Foundation
- Soderbergs Foundation
- Knut and Alice Wallenbergs Foundation
- Imperial BHF Centre of Research Excellence
- Prof. Nanna Svartz Foundation
- Swedish Rheumatism Association
- King Gustaf V 80th Anniversary Foundation
- Institute of Cardiometabolism and Nutrition (ICAN) [ANR-10-IAHU-05]
- Cancer Research UK [A10976]
- UK Medical Research Council [G9900061]
- U.S. National Institutes of Health [R01 AR047822]
- MRC [MC_U120061454, G9900061, G0900084] Funding Source: UKRI
- Wellcome Trust [083573/Z/07/Z, 089269/Z/09/Z] Funding Source: Wellcome Trust
- Cancer Research UK [13031] Funding Source: researchfish
- Medical Research Council [G9900061, MC_U120061454, G0900084] Funding Source: researchfish
Genetic mapping on fully sequenced individuals is transforming understanding of the relationship between molecular variation and variation in complex traits. Here we report a combined sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 122 phenotypes. We identify 35 causal genes involved in 31 phenotypes, implicating new genes in models of anxiety, heart disease and multiple sclerosis. The relationship between sequence and genetic variation is unexpectedly complex: at approximately 40% of quantitative trait loci, a single sequence variant cannot account for the phenotypic effect. Using comparable sequence and mapping data from mice, we show that the extent and spatial pattern of variation in inbred rats differ substantially from those of inbred mice and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据