期刊
NATURE GENETICS
卷 45, 期 2, 页码 155-163出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2506
关键词
-
资金
- Medical Research Council [MC_PC_U127561128] Funding Source: Medline
- NCATS NIH HHS [UL1 TR000124] Funding Source: Medline
- NEI NIH HHS [R01 EY018246, F32 EY021436, P30 EY014104, R01 EY023242, R01 EY018825, R01 EY022305] Funding Source: Medline
- Department of Health [SRF/01/010] Funding Source: Medline
- Chief Scientist Office [CZB/4/710, CZB/4/438] Funding Source: Medline
- MRC [MC_PC_U127561128] Funding Source: UKRI
- Chief Scientist Office [CZB/4/710, CZB/4/438] Funding Source: researchfish
- Medical Research Council [MC_PC_U127561128] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0507-10094, SRF/01/010] Funding Source: researchfish
- Public Health Agency [RRG/3240/05] Funding Source: researchfish
Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (P < 5 x 10(-8)). We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (Cl) = 1.4-1.88, P = 2.7 x 10(-10), and rs4894535 in FNDC3B had OR = 1.47,95% Cl = 1.29-1.68, P = 4.9 x 10(-9)). FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 x 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据