期刊
NATURE GENETICS
卷 44, 期 3, 页码 269-U65出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.1073
关键词
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资金
- European Community
- BioSHaRE Consortium [261433]
- Sigrid Juselius Foundation [251217]
- Academy of Finland [137870, 135973, 129269, 129429, 126925, 121584, 124282, 129378, 117787, 41071, 120386, 125876, 126775, 118081, 100499, 205585, 118555, 141054, 104781, 120315, 1114194, 139900]
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- Finnish Foundation for Cardiovascular Research
- Instrumentarium Science Foundation
- Finnish Cultural Foundation
- Aalto University School of Science and Technology
- Wellcome Trust [098051, 89061/Z/09/Z, 089062/Z/09/Z, GR069224]
- Social Insurance Institution of Finland
- Turku University Foundation
- Yrjo Jahnsson Foundation
- Emil Aaltonen Foundation
- Tampere University Hospital
- Turku University Hospital
- Juho Vainio Foundation
- Tampere Tuberculosis Foundation
- Finnish Diabetes Research Society
- Novo Nordisk Foundation
- European Science Foundation (EuroSTRESS)
- Samfundet Folkhalsan
- Finska Lakaresallskapet
- National Institute on Alcohol Abuse and Alcoholism (NIAAA) [AA-12502, AA-09203, AA-08315, AA-15416]
- Diabetes Research Foundation
- Biomedicum Helsinki and Helsinki University Central Hospital
- SALVE
- Center of Excellence in Complex Disease Genetics
- University Hospital Oulu, Biocenter, University of Oulu [75617]
- European Commission EURO-BLCS [QLG1-CT-2000-01643]
- US National Heart, Lung, and Blood Institute (NHLBI) [5R01HL087679]
- US National Institute of Mental Health (NIMH) [1RL1MH083268]
- European Network for Genetic and Genomic Epidemiology (ENGAGE) [HEALTH-F4-2007-201413]
- MRC UK [G0500539, G0600705]
- PrevMetSyn/Salve
- Academy of Finland (AKA) [118081, 139900, 118081, 139900, 135973, 135973] Funding Source: Academy of Finland (AKA)
- Medical Research Council [G0600705, G0801056B] Funding Source: researchfish
- MRC [G0600705] Funding Source: UKRI
Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 x 10(-10)) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pairs suggested that the metabolic measures reported here show higher heritability than comparable conventional metabolic phenotypes. In accordance with our expectations, SNPs at the 31 loci associated with individual metabolites account for a greater proportion of the genetic component of trait variance (up to 40%) than is typically observed for conventional serum metabolic phenotypes. The identification of such associations may provide substantial insight into cardiometabolic disorders.
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