期刊
NATURE GENETICS
卷 44, 期 8, 页码 890-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2337
关键词
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资金
- National Basic Research Program of China (973 Plan) from the Ministry of Science and Technology of China [2011CB503901, 2006CB503805]
- National Science Foundation of China [30930047]
- High-Tech Research and Development Program of China (863 Plan) [2009AA022703, 2012AA02A516, 2006AA02A406]
- Ministry of Science and Technology of China [2006BAI01A01]
- Biomedical Project from the Council of Science and Technology, Beijing [H020220030130]
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 x 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
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