期刊
NATURE GENETICS
卷 44, 期 11, 页码 1236-1242出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2443
关键词
-
资金
- Spanish Ministry of Economy and Competitiveness (MINECO) through the Instituto de Salud Carlos III (ISCIII)
- Red Tematica de Investigacion del Cancer (RTICC) of the ISCIII
- European Union's Seventh Framework Programme through the Blueprint Consortium [282510]
- Botin Foundation
- MINECO
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya)
- Portuguese Fundacao para a Ciencia e a Tecnologia
- EMBO Long-Term Fellowship
- La Caixa
- [SAF2009-08663]
- [MCyT-BIO2007-666855]
We have extensively characterized the DNA methylomes of 139 patients with chronic lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell subpopulations through the use of whole-genome bisulfite sequencing and high-density microarrays. The two molecular subtypes of CLL have differing DNA methylomes that seem to represent epigenetic imprints from distinct normal B-cell subpopulations. DNA hypomethylation in the gene body, targeting mostly enhancer sites, was the most frequent difference between naive and memory B cells and between the two molecular subtypes of CLL and normal B cells. Although DNA methylation and gene expression were poorly correlated, we identified gene-body CpG dinucleotides whose methylation was positively or negatively associated with expression. We have also recognized a DNA methylation signature that distinguishes new clinicobiological subtypes of CLL. We propose an epigenomic scenario in which differential methylation in the gene body may have functional and clinical implications in leukemogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据