期刊
NATURE GENETICS
卷 44, 期 11, 页码 1222-1226出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2438
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Ministry of Health, Labour and Welfare, Japan
- Grants-in-Aid for Scientific Research [22116010, 24390251, 23390397, 23390260, 24591667, 24659400] Funding Source: KAKEN
Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P-combined = 8.36 x 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 x 10(-20)), OR10A3-NLRP10 (P = 1.54 x 10(-22)), GLB1 (P = 2.77 x 10(-16)), CCDC80 (P = 1.56 x 10(-19)), CARD11 (P = 7.83 x ZNF365 (P = 5.85 x 10(-20)) and CYP24A1-PFDN4 (P = 1.65 x 10(-8)). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.
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