期刊
NATURE GENETICS
卷 45, 期 2, 页码 191-196出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.2505
关键词
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资金
- US National Institutes of Health (NIH) [R37CA070867, R01CA082729, R01CA124558, R01CA148667, R01CA122364]
- Ingram Professorship and Research Reward funds from the Vanderbilt University School of Medicine
- US NIH [R37CA070867, R01CA082729, R01CA064277, R01CA092585]
- National Key Scientific and Technological Project [2011ZX09307-001-04]
- National Basic Research Program [2011CB504303]
- Natural Science Foundation of China [81072383]
- Japanese Ministry of Education, Culture, Sports, Science and Technology [17015018, 221S0001]
- Basic Science Research Program through the National Research Foundation of Korea [2010-0010276]
- National Cancer Center Korea [0910220]
- National R&D Program for Cancer Control [0920330]
- Seoul RD Program [10526]
- GECCO (US NIH) [U01 CA137088, R01 CA059045]
- DALS (US NIH) [R01 CA048998]
- Colo23 (US NIH) [R01 CA060987]
- DACHS (German Federal Ministry of Education and Research) [BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, CH 117/1-1, 01KH0404, 01ER0814]
- HPFS (US NIH) [P01 CA055075, UM1 CA167552, R01 137178, P50 CA127003]
- MEC (US NIH) [R37 CA054281, P01 CA033619, R01 CA063464]
- NHS (US NIH) [R01 137178, P50 CA127003, P01 CA087969]
- OFCCR (US NIH) [U01 CA074783]
- PMH (US NIH) [R01 CA076366]
- PHS (US NIH) [CA042182]
- VITAL (US NIH) [K05 CA154337]
- WHI (US NIH) [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C, 268200764316C]
- PLCO (US NIH) [Z01 CP 010200, U01 HG004446, U01 HG 004438]
- National Cancer Institute, US NIH, under REA [CA-95-011]
- National Cancer Institute [U01CA122839]
- GL2 grant from the Ontario Research Fund
- Canadian Institutes of Health Research
- Cancer Risk Evaluation (CaRE) Program grant from the Canadian Cancer Society Research Institute
- Ontario Institute for Cancer Research
- Ontario Ministry of Economic Development and Innovation
- Regional Hospital Clinical Research Program (PHRC)
- Regional Council of Pays de is Loire
- Groupement des Entreprises Francaises dans la Lutte contre le Cancer (GEFLUC)
- Association Anne de Bretagne Genetique
- Ligue Regionale Contre le Cancer (LRCC)
- Korea Health Promotion Institute [0920330] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 x 10(-7) to 3.77 x 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 x 10(-10) for rs647161 (5q31.1), 6.64 x 10(-9) for rs2423279 (20p12.3) and 3.06 x 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.
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