期刊
NATURE GENETICS
卷 44, 期 5, 页码 522-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2227
关键词
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资金
- Translational Resource Center (TRC) [NSC100-2325-B-001-023]
- National Center for Genome Medicine (NCGM) at Academia Sinica [NSC100-2319-B-001-001]
- Academia Sinica Genomic Medicine Multicenter Study, Taiwan [40-05-GMM]
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 x 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
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