期刊
NATURE GENETICS
卷 44, 期 3, 页码 352-U168出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.1072
关键词
-
资金
- Wellcome Trust [079126/Z/06/Z, 090532/Z/09/Z]
- UK National Health Service (NHS) National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- NIHR
- Wolfson Royal Society
- NHS NIHR Oxford Biomedical Research Centre
- UK Clinical Research Collaboration (UKCRC) (MRC UK) [G0800778]
- UK Clinical Research Collaboration (UKCRC) (Wellcome Trust) [087646/2/08/Z]
- MRC [G0800778] Funding Source: UKRI
- Wellcome Trust [079126/Z/06/Z] Funding Source: Wellcome Trust
- Medical Research Council [G0800778] Funding Source: researchfish
Streptococcus pneumoniae ('pneumococcus') causes an estimated 14.5 million cases of serious disease and 826,000 deaths annually in children under 5 years of age(1). The highly effective introduction of the PCV7 pneumococcal vaccine in 2000 in the United States(2,3) provided an unprecedented opportunity to investigate the response of an important pathogen to widespread, vaccine-induced selective pressure. Here, we use array-based sequencing of 62 isolates from a US national monitoring program to study five independent instances of vaccine escape recombination(4), showing the simultaneous transfer of multiple and often large (up to at least 44 kb) DNA fragments. We show that one such new strain quickly became established, spreading from east to west across the United States. These observations clarify the roles of recombination and selection in the population genomics of pneumococcus and provide proof of principle of the considerable value of combining genomic and epidemiological information in the surveillance and enhanced understanding of infectious diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据