期刊
NATURE GENETICS
卷 44, 期 7, 页码 770-U197出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.2293
关键词
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资金
- Cancer Research UK [C1298/A8362, C348/A12076, C31250/A10107, C10195/A12996, C490/A10124]
- Centre Grant from Core as part of the Digestive Cancer Campaign
- National Cancer Research Network
- NHS via the Biological Research Centre of the NIHR at the Royal Marsden Hospital NHS Trust
- St. George's Hospital Medical School
- Institute of Cancer Research
- Oxford Comprehensive Biomedical Research Centre
- European Union [258236]
- CORE Charity
- MRC
- UK Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC
- Royal Society
- Chief Scientist Office of the Scottish Government
- Research into Ageing
- EPSRC
- ESRC
- Kidani Trust
- Tenovus
- Cancer Research Wales
- CRUK [C10314/A4886]
- Wales Assembly Government NISCHR Cancer Genetics BRU
- Wales Gene Park
- Wellcome Trust [076113/C/04/Z]
- Juvenile Diabetes Research Foundation [WT061858]
- NIHR of England
- Swedish Cancer Society
- Swedish Scientific Research Council
- Stockholm Cancer Foundation
- Academy of Finland (Finnish Centre of Excellence Program)
- Finnish Cancer Society
- Sigrid Juselius Foundation
- US National Cancer Institute, National Institutes of Health [CA-95-011, U01CA122839]
- Australasian Colorectal Cancer Family Registry [U01 CA097735]
- Familial Colorectal Neoplasia Collaborative Group [U01 CA074799]
- Ontario Registry for Studies of Familial Colorectal Cancer [U01 CA074783]
- Seattle Colorectal Cancer Family Registry [U01 CA074794]
- Ministry of Education, Culture, Sports, Science and Technology of the Japanese government
- [090532/Z/09/Z]
- Cancer Research UK [13154, 12076, 10589] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
- Medical Research Council [998069, G1002033, G0700704B, MC_U122861325, MC_U127527198, MC_PC_U127527198] Funding Source: researchfish
- Tenovus Cancer Care [PhD2009/L27] Funding Source: researchfish
- MRC [MC_PC_U127527198, MC_U122861325, MC_U127527198, G1002033] Funding Source: UKRI
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.
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