期刊
NATURE GENETICS
卷 44, 期 12, 页码 1289-1291出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2473
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资金
- NINDS NIH HHS [R37 NS027036, R01 NS027036] Funding Source: Medline
- Wellcome Trust [089701] Funding Source: Medline
A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.
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