期刊
NATURE GENETICS
卷 43, 期 9, 页码 887-U103出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.888
关键词
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资金
- Office of the Director, NIH
- National Heart, Lung, and Blood Institute [HL087665, HL070831, HL072414, HL049596, HL064307, HL064313, HL075419, HL65899, HL083069, HL066289, HL101543, HL101651, HL079055, HL087699, HL49612, HL075417, HL04266, HL072433, HL061768, HL076647, HL087680, HL078885, HL088133, HL87665, HL69116, HL69130, HL69149]
- National Institutes of Allergy and Infectious Disease [AI070503, AI079139, AI061774, AI50024, AI44840, AI41040, AI077439]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK064695]
- National Institutes of Environmental Health Sciences [ES09606, ES018176, ES015903, ES007048, ES009581, R826708, RD831861, ES011627, ES015794]
- Division of Intramural Research [Z01 ES049019]
- National Center for Research Resources [RR03048]
- Environmental Protection Agency [83213901, R-826724]
- American Asthma Foundation
- Fund for Henry Ford Hospital
- Mary Beryl Patch Turnbull Scholar Program
- National Council of Science and Technology (Mexico) [26206-M]
- Centers for Disease Control, US
- Eudowood Foundation
- Flight Attendant Medical Research Institute (FAMRI)
- Robert Wood Johnson Foundation (RWJF)
- Sandler Foundation
- Medical Research Council [G1000758, G0801056B, G1000758B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10212] Funding Source: researchfish
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 x 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
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