期刊
NATURE GENETICS
卷 43, 期 4, 页码 339-U89出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.782
关键词
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资金
- European Community [LSHM-CT-2007-037273]
- AstraZeneca
- British Heart Foundation
- Oxford British Heart Foundation Centre of Research Excellence
- Wellcome Trust [075491/Z/04, 084723/Z/08/Z, 081917/Z/07/Z, 091746/Z/10/Z]
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Swedish Heart-Lung Foundation
- Torsten and Ragnar Soderberg Foundation
- Karolinska Institutet and Stockholm County Council
- Foundation for Strategic Research
- Stockholm County Council [560283]
- UK Medical Research Council
- Merck Co
- Roche Vitamins Ltd.
- Oxford BHF Centre of Research Excellence
- University of Cambridge, UK
- Centre for Non-Communicable Diseases, Pakistan
- National Institute for Health Research Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust, Ealing Hospital NHS Trust
- British Heart Foundation [SP/04/002]
- Medical Research Council [G0700931, G0601966]
- National Institute for Health Research [RP-PG-0407-10371]
- Aarno Koskelo Foundation
- Finnish Foundation for Cardiovascular Research
- European Commission (FAD) [Health-F22008-200647]
- DASTI (Danish Agency for Science, Technology and Innovation)
- [HEALTH-2007-A-201668]
- Wellcome Trust [084723/Z/08/Z] Funding Source: Wellcome Trust
- MRC [G0601966, G0801056, MC_U137686857, G0700931, G9521010] Funding Source: UKRI
- British Heart Foundation [RG/08/014/24067] Funding Source: researchfish
- Medical Research Council [G0601966, MC_U137686857, G0700931, G0801056, G9521010, G0801056B] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0407-10371] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [RP-PG-0407-10371] Funding Source: National Institutes of Health Research (NIHR)
Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)(1-7), a modest number considering the apparent heritability of CAD(8). All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide association studies of CAD, with similar to 575,000 genotyped SNPs in a discovery dataset comprising 15,420 individuals with CAD (cases) (8,424 Europeans and 6,996 South Asians) and 15,062 controls. There was little evidence for ancestry-specific associations, supporting the use of combined analyses. Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 x 10(-8) in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11. The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.
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