期刊
NATURE GENETICS
卷 43, 期 7, 页码 648-U173出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.847
关键词
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资金
- National Institute of General Medical Sciences (NIGMS) [GM-076468]
- US National Institutes of Health (NIH) [R01 GM74245]
- Czech Science Foundation [206-08-0640]
- NIH [GM067553-04, P50 MH090338]
- University of North Carolina (UNC)
- [ISEM 2010-141]
- Direct For Biological Sciences [0746560] Funding Source: National Science Foundation
- Division Of Environmental Biology [0746560] Funding Source: National Science Foundation
Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process. The subspecific origin, haplotype diversity and identity by descent maps can be visualized using the Mouse Phylogeny Viewer (see URLs).
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