期刊
NATURE GENETICS
卷 43, 期 3, 页码 185-187出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.760
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资金
- National Cancer Institute, National Institutes of Health, Department of Health and Human Services [CA131332, CA087969, CA049449, CA128931, CA116201, CA075016, CA122340, CA089393]
- Breast Cancer Research Fund
- National Cancer Institute's Cancer Markers of Susceptibility (CGEMS) initiative
- Cancer Research UK
- Marit and Hans Rausing's Initiative against Breast Cancer, National Institutes of Health
- Susan Komen Foundation
- Agency for Science, Technology and Research of Singapore (A*STAR)
- Campbell Family Institute for Breast Cancer Research
- Ontario Ministry of Health and Long Term Care
- MRC [MC_U106188470, G0701863] Funding Source: UKRI
- Cancer Research UK [10118, 11022] Funding Source: researchfish
- Medical Research Council [MC_U106188470, G0701863, MC_U106179471] Funding Source: researchfish
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 x 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
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