期刊
NATURE GENETICS
卷 43, 期 8, 页码 741-743出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.877
关键词
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资金
- NIH [U01-HG005715]
- Alfred P. Sloan Research Fellowship
The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.
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