期刊
NATURE GENETICS
卷 43, 期 12, 页码 1224-U79出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.980
关键词
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资金
- 973 Program [2010CB529600, 2009AA022701, 2006AA02A407]
- Natural Science Foundation of China [81130022, 81121001, 31000553]
- Foundation for the Author of National Excellent Doctoral Dissertation of China [201026]
- Program for New Century Excellent Talents in University [NCET-09-0550]
- Shanghai Municipal Health Bureau [2008095]
- Shanghai Changning Health Bureau [2008406002]
- Shanghai Municipal Commission [09DJ1400601]
- National Key Technology RD Program [2006BAI05A09]
- Shanghai Leading Academic Discipline Project [B205]
- Medical Research Council [G9817803B] Funding Source: researchfish
Schizophrenia is a severe mental disorder affecting similar to 1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 x 10(-10)) and 1q24.2 (rs10489202, P = 9.50 x 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.
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